Research

Active Projects

The lab of Mike Strauss at Université de Montréal studies viral structure using cryo‑electron microscopy (cryoEM). We use the electron microscope and other biophysical methods to examine a number of other interesting topics in biology.

Poliovirus Cell Entry

Finding the molecular mechanism of infection

We use poliovirus as a model for picornavirus infection to study the infection pathway by cryoEM.

Poliovirus Antibody Complexes

Finding the molecular mechanism of infection

Complexes with antibodies can trap intermediates in the infection pathway by cryoEM.

Bacterial Nanowires

Electrically conductive filaments

We are examining the structure of specialised extensions of bacteria that can conduct electricity.

Seneca Valley Virus Characterisation

Pursuing oncolytic viral therapeutics

This interesting virus is in clinical trials for treatment of specific cancers. We want to investigate the mechanism of infection.

Membrane Protein Receptors

Structure and mechanisms of fully liganded Insulin Receptor

Biophysical and structural analysis of membrane proteins can help explain their physiological function and help explain mechanisms of disease.

Electron Spectroscopic Imaging, EELS and STEM

Ultrastructure of chromatin

Using elemental mapping we are looking at the organisation of genomic material within cells.

Location

Campus Montréal

Research Support

Granting Agencies

Generous Support from Donors